Reaktion #302903

ord-6abf863f88864c4eae7650480f24dadc

Reaktionsgleichung

CCCCCCCCCCCCCCCCBr
1-bromohexadecane
Nc1ccn(C[C@H]2COP(=O)(O)CO2)c(=O)n1
cyclic cidofovir
→
CCCCCCCCCCCCCCCCOP1(=O)CO[C@@H](Cn2ccc(N)nc2=O)CO1
title compound
Ausbeute 55.0%
CCCCCCCCCCCCCCCCOP1(=O)CO[C@@H](Cn2ccc(N)nc2=O)CO1
Hexadecyl Cyclic Cidofovir
Ausbeute 55.0%

Edukte

CCCCCCCCCCCCCCCCBr
1-bromohexadecane
Nc1ccn(C[C@H]2COP(=O)(O)CO2)c(=O)n1
cyclic cidofovir

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared using the same procedure as described for Example 1 using 1-bromohexadecane and cyclic cidofovir.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08193167B2uspto-grants-2012_06