Reaktion #302892

Reaktionsgleichung

2,3-dimethylbenzylamine

2-chloroethylisothiocyanate

→

title compound

Ausbeute 76.0%

((2,3-dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Ausbeute 76.0%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   Sonstigea solid precipitate that had formed
3. 3
   Filtrationwas collected by filtration
4. 4
   WaschenThe solid was rinsed with diethyl ether
5. 5
   Sonstigewas dried under reduced pressure

Vorschrift

Under a dry nitrogen atmosphere, a stirred mixture of 5.56 grams (0.041 mole) of 2,3-dimethylbenzylamine and 5.0 grams (0.041 mole) of 2-chloroethylisothiocyanate in 100 mL of 1,4-dioxane was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 8.0 grams of the title compound. The NMR spectrum was consistent with the proposed structure.

Quelle