Reaktion #302891

Reaktionsgleichung

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Compound C7

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

sodium hydroxide

→

title compound

Ausbeute 98.9%

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine

Ausbeute 98.9%

Lösungsmittel

water

water

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONpoured into a separatory funnel
2. 2
   Extraktionwas extracted with two 50 mL portions of diethyl ether
3. 3
   Trocknendried with sodium sulfite
4. 4
   Filtrationfiltered
5. 5
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

A mixture of 0.36 gram (0.0012 mole) of ((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride (Compound C7) in one mL of water was added to a stirred, cold (ice water bath) mixture of 0.05 gram (0.0013 mole) of sodium hydroxide in 10 mL of water and 10 mL of diethyl ether. The reaction mixture was stirred for 10 minutes, poured into a separatory funnel and was extracted with two 50 mL portions of diethyl ether. The extracts were combined, dried with sodium sulfite and filtered. The filtrate was concentrated under reduced pressure to yield 0.31 gram of the title compound as a white solid. The NMR spectrum was consistent with the proposed structure.

Quelle