Reaktion #302890

Reaktionsgleichung

2,3-dichlorobenzylamine

2-chloroethylisothiocyanate

→

title compound

Ausbeute 163.2%

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Ausbeute 163.2%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas placed in a sealed reaction vial
2. 2
   Temperaturto cool
3. 3
   Sonstigea solid precipitate that had formed
4. 4
   Filtrationwas collected by filtration
5. 5
   WaschenThe solid was rinsed with diethyl ether
6. 6
   Sonstigewas dried under reduced pressure

Vorschrift

A mixture of 0.5 gram (0.0028 mole) of 2,3-dichlorobenzylamine and 0.27 gram (0.0081 mole) of 2-chloroethylisothiocyanate in 10 mL of 1,4-dioxane was placed in a sealed reaction vial. The reaction mixture was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 0.68 gram of the title compound. The NMR spectrum was consistent with the proposed structure.

Quelle