Reaktion #2984

Reaktionsgleichung

KCN

3-(7-methoxy-1-naphthyl)propyl mesylate

3-(7-METHOXY-1-NAPHTHYL)PROPYL MESYLATE

→

4-(7-METHOXY-1-NAPHTHYL)BUTYRONITRILE

Lösungsmittel

DMSO

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux for 2 h
2. 2
   Temperaturto cool
3. 3
   ExtraktionThe resulting mixture is extracted with ether
4. 4
   WaschenThe organic phase is washed with water
5. 5
   Trocknendried over CaCl2
6. 6
   Sonstigeevaporated
7. 7
   SonstigeThe product obtained
8. 8
   Sonstigeis recrystallized

Vorschrift

In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.

Quelle