Reaktion #296

Reaktionsgleichung

O=c1cc(N2CCOCC2)nc2c

CNC(=O)CN1CCOCC1

→

CN(C(=O)CN1CCOCC1)c1

Lösungsmittel

C1COCCO1

Reaktionsbedingungen

Vorschrift

A solution of 6-(2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)dibenzo[b,d]thiophen-2-yl trifluoromethanesulfonate (100mg, 0.18 mmol) in dry dioxane (1 ml) was added to a stirred mixture of N-methyl-2-morpholinoacetamide (33.8 mg, 0.21 mmol), TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0) (4.08 mg, 4.45 µmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (5.15 mg, 8.90 µmol) and cesium carbonate (232 mg, 0.71 mmol) in dry dioxane (1 ml) . The resulting mixture was stirred under nitrogen at 110 °C for 3 hours. UPLC analysis showed no appreciable product only hydrolysis of the triflate - not isolated , reaction abandonned

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