Reaktion #2951

Reaktionsgleichung

ethyl 3-oxo-4,4,4-trifluoroacetoacetate

CH3COONa

water

phenyldiazonium chloride

→

title compound

Ausbeute 60.0%

Ethyl 2-phenylhydrazono-4,4,4-trifluoro-3-oxobutyrate

Ausbeute 60.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeas described in preparation 2
2. 2
   SonstigeThe crude product was purified by chromatography on silica gel (hexane/Et2O 0%→25%)

Vorschrift

7.3 ml (0.05 mol) of ethyl 3-oxo-4,4,4-trifluoroacetoacetate, 6 g (0.073 mol) of CH3COONa, 20 ml of water, 37.5 ml of ethanol and a solution of 0.05 mol of phenyldiazonium chloride were treated as described in preparation 2. The crude product was purified by chromatography on silica gel (hexane/Et2O 0%→25%) obtaining 8.65 g of the title compound. M.p.=78°-80° C.

Quelle