Reaktion #2950

Reaktionsgleichung

N,N-diisopropyl-3-oxobutyramide

NaOH

phenyldiazonium chloride

→

title compound

Ausbeute 68.2%

N,N-Diisopropyl-2-phenylhydrazono-3-oxobutyramide

Ausbeute 68.2%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeas described in preparation 8
2. 2
   SonstigeThe crude reaction mixture
3. 3
   Sonstigewas purified by chromatography on silica gel (hexane/Et2O 95:5)

Vorschrift

7.0 g (0.038 mol) of N,N-diisopropyl-3-oxobutyramide, a solution of 5.3 g (0.133 mol) of NaOH in 58 ml of water and 0.04 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 95:5) obtaining 7.5 g of the title compound which was used as such in the subsequent step. M.p.=143°-145° C.

Quelle