Reaktion #2947

ord-eb592b1203c74e969732293b7513ee02

Reaktionsgleichung

C=C1CC(=O)O1.CC(C)=O
diketene acetone
CNC
dimethylamine
→
CC(=O)CC(=O)N(C)C
title compound
CC(=O)CC(=O)N(C)C
N,N-Dimethyl-3-oxobutyramide

Edukte

C=C1CC(=O)O1.CC(C)=O
diketene acetone
CNC
dimethylamine

Reagenzien

Keine

Lösungsmittel

Cc1ccccc1
toluene

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe solvent was removed in vacuo
  2. 2
    Sonstigethe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

Vorschrift

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05731322uspto-grants-1998_03