Reaktion #2916

Reaktionsgleichung

sodium hydrogen carbonate

1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

hydrogen chloride

diethylether

→

title compound

1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethene

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted with dichloromethane
2. 2
   SonstigeThe material thus obtained
3. 3
   Sonstigewas purified by flash chromatography

Vorschrift

1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol (900 mg) in dry chloroform was treated with 1M anhydrous hydrogen chloride in diethylether (1.1 equivalents). After 10 minutes at room temperature, aqueous sodium hydrogen carbonate was added and the mixture was extracted with dichloromethane. The material thus obtained was purified by flash chromatography to give the title compound as an almost colourless liquid.

Quelle