Reaktion #2904

Reaktionsgleichung

water

3-Bromofuran

n-butyllithium

5-acetyl-4-methylthiazole

→

1-(3-Furyl)-1-(4-methyl-5-thiazolyl)ethanol

Lösungsmittel

diethylether

diethylether

diethylether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter a further 3 hours at -70° C.
2. 2
   workup.WAITwas then left overnight
3. 3
   Extraktionextracted with diethylether
4. 4
   SonstigeThe product thus obtained
5. 5
   Sonstigewas crystallised from diethylether, m.p. 102°-104° C.

Vorschrift

3-Bromofuran (6.8 g) in diethylether (15 ml) was added dropwise to n-butyllithium (2.5M solution in hexane, 18.4 ml) in diethylether (20 ml) at -70° C. under a nitrogen atmosphere. After 1 hour, 5-acetyl-4-methylthiazole (5 g) in diethylether (15 ml) was added dropwise. After a further 3 hours at -70° C., the mixture was allowed to warm to room temperature and was then left overnight. The mixture was poured into water and extracted with diethylether. The product thus obtained was crystallised from diethylether, m.p. 102°-104° C.

Quelle