Reaktion #2903

Reaktionsgleichung

sodium hydrogen carbonate

n-butyllithium

Thiophene

5-Acetyl-4-methyloxazole

→

title compound

1-(4-Methyl-5-oxazolyl)-1-(2-thienyl)ethanol

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm to -20° C.
2. 2
   Temperaturafter 1 hour was cooled to -70° C
3. 3
   Temperaturto warm the room temperature
4. 4
   Extraktionthe mixture was extracted with diethylether
5. 5
   SonstigeThe material thus obtained
6. 6
   Sonstigewas purified by flash chromatography

Vorschrift

Thiophene (3.36 g) in dry tetrahydrofuran (20 ml) was stirred and cooled to -40° C. under a dry nitrogen atmosphere and n-butyllithium (2.5M solution in hexane, 16 ml) was added dropwise. The mixture was allowed to warm to -20° C. and then after 1 hour was cooled to -70° C. 5-Acetyl-4-methyloxazole (5 g) in dry tetrahydrofuran (15 ml) was added dropwise. After a further 1 hour the mixture was allowed to warm the room temperature and was stirred for a further 2 hours. Aqueous sodium hydrogen carbonate was added and the mixture was extracted with diethylether. The material thus obtained was purified by flash chromatography to give the title compound. M.p. 84°-85° C.

Quelle