Reaktion #2901

Reaktionsgleichung

ethanol

3-Furyl-4-methyl-5-oxazolyl ketone

methyllithium

sodium chloride

→

1-(3-furyl)-1-(4-methyl-5-oxazolyl)ethanol

Lösungsmittel

diethylether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with dichloromethane
2. 2
   SonstigeChromatography and crystallisation

Vorschrift

3-Furyl-4-methyl-5-oxazolyl ketone (1 g) in dry diethylether (15 ml) at -70° C. under a nitrogen atmosphere was treated dropwise with methyllithium (1.5M solution in diethylether, 4.1 ml). After 45 minutes the reaction mixture was allowed to warm to room temperature and ethanol (2 ml) was added. The mixture was poured into saturated aqueous sodium chloride and extracted with dichloromethane. Chromatography and crystallisation then gave 1-(3-furyl)-1-(4-methyl-5-oxazolyl)ethanol identical to the material obtained in (a) above.

Quelle