Reaktion #2897

Reaktionsgleichung

Hydroxy(tosyloxy)iodobenzene

1,1,1-trifluoropentane-2,4-dione

thiourea

→

title compound

5-Acetyl-2-amino-4-trifluoromethylthiazole

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturunder reflux for 45 minutes
3. 3
   Temperaturcooled
4. 4
   TemperaturThe mixture was heated
5. 5
   Temperaturunder reflux for 4 hours
6. 6
   workup.WAITleft
7. 7
   SonstigeEvaporation and crystallisation of the residue from dichloromethane

Vorschrift

Hydroxy(tosyloxy)iodobenzene (78.5 g) was added to a solution of 1,1,1-trifluoropentane-2,4-dione in acetonitrile (500 ml). The mixture was heated under reflux for 45 minutes, then cooled, and thiourea (15.2 g) was added. The mixture was heated under reflux for 4 hours and then left to stand overnight. Evaporation and crystallisation of the residue from dichloromethane gave the title compound.

Quelle