Reaktion #2890

Reaktionsgleichung

sodium hydrogen carbonate

4-Methyl-5-oxazolecarbonyl chloride

N,O-dimethylhydroxylamine hydrochloride

pyridine

→

title compound

N-Methoxy-N-methyl-4-methyl-5-oxazolecarboxamide

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic layer separated
2. 2
   ExtraktionThe aqueous layer was extracted with dichloromethane
3. 3
   WaschenThe combined organic layers were washed
4. 4
   Sonstigedried
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe residue was purified by flash chromatography

Vorschrift

4-Methyl-5-oxazolecarbonyl chloride (15 g) and N,O-dimethylhydroxylamine hydrochloride (11 g) in dry chloroform (100 ml) were cooled to 0° C. and dry pyridine (28.5 g) was added. The mixture was allowed to warm to room temperature. After 30 minutes aqueous sodium hydrogen carbonate was added and the organic layer separated. The aqueous layer was extracted with dichloromethane. The combined organic layers were washed, dried and evaporated. The residue was purified by flash chromatography to yield the title compound as a white solid. M.p. 59°-60° C.

Quelle