Reaktion #2877

ord-806352f5d1f24257a0c79e1cedfd6e4a

Reaktionsgleichung

Cl.N#Cc1ccc(F)c(CN2CC[C@H](N)C2=O)c1
3-(S)-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-fluoro-benzonitrile hydrochloride
O=S(=O)(Cl)c1ccc(-c2cccnc2)s1
5-pyridin-3-yl-thiophene-2-sulfonyl chloride
→
N#Cc1ccc(F)c(CN2CC[C@H](NS(=O)(=O)c3ccc(-c4cccnc4)s3)C2=O)c1
title compound
N#Cc1ccc(F)c(CN2CC[C@H](NS(=O)(=O)c3ccc(-c4cccnc4)s3)C2=O)c1
5-Pyridin-3-yl-thiophene-2-sulfonic acid [1-(5-cyano-2-fluoro-benzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

Edukte

Cl.N#Cc1ccc(F)c(CN2CC[C@H](N)C2=O)c1
3-(S)-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-fluoro-benzonitrile hydrochloride
O=S(=O)(Cl)c1ccc(-c2cccnc2)s1
5-pyridin-3-yl-thiophene-2-sulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude product is triturated with Et2O

Vorschrift

The title compound is prepared from 3-(S)-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-fluoro-benzonitrile hydrochloride as described in EXAMPLE 17, Part G substituting 5-pyridin-3-yl-thiophene-2-sulfonyl chloride in place of 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The crude product is triturated with Et2O to give the title compound as a white solid

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05731315uspto-grants-1998_03