Reaktion #2876

Reaktionsgleichung

N-bromosuccinimide

5-bromo-2-fluoro-benzyl alcohol

triphenyl phosphine

→

title compound

Ausbeute 96.7%

5-Bromo-2-fluoro-benzyl bromide

Ausbeute 96.7%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe ice bath is removed
2. 2
   SonstigeThe crude product is purified by column chromatography
3. 3
   Wascheneluting with 5% EtOAc/hexanes

Vorschrift

To a solution of 5-bromo-2-fluoro-benzyl alcohol (3.10 g, 15.1 mmol) in 30 mL of THF at 10° C. is added triphenyl phosphine (4.10 g, 15.6 mmol) followed by N-bromosuccinimide (2.67 g, 15.0 mmol). The ice bath is removed and the resulting solution is stirred for 20 min at room temperature. The crude product is purified by column chromatography eluting with 5% EtOAc/hexanes to give the title compound (3.90 g, 14.5 mmol).

Quelle