Reaktion #2862

Reaktionsgleichung

5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride

4-amino-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile dihydrochloride

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title compound

5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(2-amino-5-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude product is purified by column chromatography
2. 2
   Wascheneluting with a gradient of 10% EtOAc/CH2Cl2 to 25% EtOAc/CH2Cl2
3. 3
   Sonstigeto afford a white solid

Vorschrift

The title compound is prepared from 4-amino-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile dihydrochloride as described in EXAMPLE 17, Part F using 5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride in place of 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 10% EtOAc/CH2Cl2 to 25% EtOAc/CH2Cl2 to afford a white solid.

Quelle