Reaktion #2861

ord-7d83168d7ce54c43b52724a182b35f94

Reaktionsgleichung

O=S(=O)(Cl)c1cc2nc(Cl)ccc2s1
5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride
Cl.N#Cc1ccc(O)c(CN2CC[C@H](N)C2=O)c1
4-hydroxy-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride
→
N#Cc1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4nc(Cl)ccc4s3)C2=O)c1
title compound
N#Cc1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4nc(Cl)ccc4s3)C2=O)c1
5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyano-2-hydroxybenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

Edukte

O=S(=O)(Cl)c1cc2nc(Cl)ccc2s1
5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride
Cl.N#Cc1ccc(O)c(CN2CC[C@H](N)C2=O)c1
4-hydroxy-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product is obtained as a white solid

Vorschrift

The title compound is prepared from 4-hydroxy-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride as described in EXAMPLE 17, Part F using 5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride in place of 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The product is obtained as a white solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05731315uspto-grants-1998_03