Reaktion #2852

Reaktionsgleichung

sodium sulfite

salicylaldehyde

Cl2

ICl

→

title compound

2-Hydroxy-5-iodo-benzaldehyde

Lösungsmittel

CH2Cl2

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe layers are separated
2. 2
   WaschenThe organic layer is washed with water
3. 3
   TrocknenThe organic layer is dried over MgSO4
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated
6. 6
   SonstigeThe resulting crude material is recrystallized from cyclohexane

Vorschrift

To a solution of salicylaldehyde (10 g, 82 mmol) in 50 mL of CH2 Cl2 is added 22 mL of a 1M ICl solution in CH2Cl2. The solution is stirred for 14 h. After this time, a saturated solution of sodium sulfite is added until the color is discharged. The solution is diluted with CH2Cl2. The layers are separated. The organic layer is washed with water. The organic layer is dried over MgSO4, filtered and concentrated. The resulting crude material is recrystallized from cyclohexane to give the title compound (7.2 g, 32 mmol) as white solid.

Quelle