Reaktion #2842

Reaktionsgleichung

triethylamine

3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride

benzo[b]thiophene-2-sulfonyl chloride

→

title compound

Ausbeute 79.0%

Benzo[b]thiophene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

Ausbeute 79.0%

Lösungsmittel

EtOAc

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe solution is washed with 1N HCl, saturated NaHCO3, and saturated NaCl
2. 2
   TrocknenThe organic layer is dried over MgSO4
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated

Vorschrift

To a solution of 3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride (0.36 g, 1.43 mmol) in 15 mL of CH2Cl2 is added benzo[b]thiophene-2-sulfonyl chloride (0.32 g, 1.38 mmol). To the resulting solution is added triethylamine (0.29 g, 2.88 mmol). After 16 h, the solution is diluted with EtOAc. The solution is washed with 1N HCl, saturated NaHCO3, and saturated NaCl. The organic layer is dried over MgSO4, filtered and concentrated. The title compound (0.45 g, 1.09 mmol) is obtained as white solid.

Quelle