Reaktion #2836

Reaktionsgleichung

(-)-(R)-2-methoxy-propanol

(+)-(R)-2-methoxy-propionic acid

lithium aluminium hydride

→

(+)-(S)-2-methoxy-propanol

(-)-(S)-2-methoxy-propionic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis obtained with a boiling point of 70° C. under a pressure of 76 mbar
2. 2
   Sonstigea specific rotation of [α]D25 =-15.8° (c=100)

Vorschrift

By reduction of the (+)-(R)-2-methoxy-propionic acid known from the prior art with lithium aluminium hydride (LiAlH4) the (-)-(R)-2-methoxy-propanol is obtained with a boiling point of 70° C. under a pressure of 76 mbar and a specific rotation of [α]D25 =-15.8° (c=100). The corresponding (+)-(S)-2-methoxy-propanol with a boiling point of 70° C. under a pressure of 76 mbar and a rotation of [α]D25 =+16.5° (c=100) is obtained analogously from the equally well known (-)-(S)-2-methoxy-propionic acid.

Quelle