Reaktion #2801

Reaktionsgleichung

hydrochloric acid

2-(bis-methylsulfonyl-methyleneamino)-1-(10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0 1,5]dec-4-yl)-3-(2-vinyl-phenyl)-propan-1-one

tetrahydrofuran

→

2-amino-3-(2-vinyl-phenyl)-propionic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITThe reaction is conducted at a temperature range of from -10° C. to room temperature and for a period of time
2. 2
   workup.WAITranging from 30 minutes to 20 hours
3. 3
   SonstigeEvaporation of the solvent
4. 4
   workup.WAITThe reaction is conducted at a temperature range of from -10° C. to room temperature and for a period of time
5. 5
   workup.WAITranging from 30 minutes to 10 hours

Vorschrift

For example, the appropriate 2-(bis-methylsulfonyl-methyleneamino)-1-(10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0 1,5]dec-4-yl)-3-(2-vinyl-phenyl)-propan-1-one derivative of structure (5) is treated with a suitable acid such as aqueous hydrochloric acid in a suitable organic solvent such as tetrahydrofuran. The reaction is conducted at a temperature range of from -10° C. to room temperature and for a period of time ranging from 30 minutes to 20 hours. Evaporation of the solvent followed by treatment with inorganic base such as aqueous lithium hydroxide in a suitable organic solvent, such as tetrahydrofuran. The reaction is conducted at a temperature range of from -10° C. to room temperature and for a period of time ranging from 30 minutes to 10 hours. After acidification, the corresponding 2-amino-3-(2-vinyl-phenyl)-propionic acid derivative of structure (6) was isolated by evaporation of solvents.

Quelle