Reaktion #2791

Reaktionsgleichung

water

n-butyl lithium

diethoxyphosphinylmethanesulfonate lithium salt

acrylonitrile

→

3-cyano-1-diethoxyphosphinylpropanesulfonic acid lithium salt

Lösungsmittel

acetic acid

tetrahydrofuran

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto warm to -15°
2. 2
   workup.STIRRINGis stirred at this temperature for about one hour
3. 3
   workup.STIRRINGThe reaction mixture is stirred for 1 hour at -15°
4. 4
   workup.STIRRINGIt is stirred at ambient temperature for several hours
5. 5
   EinengenThe reaction mixture is concentrated under vacuum on a rotary evaporator
6. 6
   Sonstigeto get rid of the THF
7. 7
   Extraktionthe aqueous layer is extracted with ether
8. 8
   Sonstigeto remove some impurities
9. 9
   SonstigeThe water layer is evaporated to dryness under vacuum
10. 10
    Sonstigethe resulting residue is purified by flash chromatography on silica gel

Vorschrift

A suspension of 2.38 g (0.01 mole) of diethoxyphosphinylmethanesulfonate lithium salt (Carretero, et al.; Tetrahedron, 43, 5125 (1987)) in 50 ml of anhydrous tetrahydrofuran is stirred in a -40° bath under a dry nitrogen atmosphere. To this is added n-butyl lithium (4.4 ml of 2.5M solution in hexanes; 0.011 mole) via syringe over 5 minutes. The reaction mixture is allowed to warm to -15° and is stirred at this temperature for about one hour. To it is then added rapidly a solution of 0.53 g (0.01 mole) of acrylonitrile in 3 ml of anhydrous THF. The reaction mixture is stirred for 1 hour at -15° , and is then allowed to warm to room temperature over several hours as the bath warms up. It is stirred at ambient temperature for several hours, and then is quenched by addition of 50 ml of water containing 0.6 g (0.01 mole) of acetic acid. The reaction mixture is concentrated under vacuum on a rotary evaporator to get rid of the THF, and the aqueous layer is extracted with ether to remove some impurities. The water layer is evaporated to dryness under vacuum, and the resulting residue is purified by flash chromatography on silica gel using chloroform/methanol as eluant, to afford 3-cyano-1-diethoxyphosphinylpropanesulfonic acid lithium salt.

Quelle