Reaktion #2777

ord-989c68d91dfc4d74a9b62cfdff0165f9

Reaktionsgleichung

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O
biotin-N-hydroxysuccinimide
NCCc1ccc(O)cc1
tyramine
CC[NH+](CC)CC.O=C([O-])O
triethylammonium bicarbonate
→
NCCc1ccc(O)cc1.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21
biotin tyramine

Edukte

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O
biotin-N-hydroxysuccinimide
NCCc1ccc(O)cc1
tyramine
CC[NH+](CC)CC.O=C([O-])O
triethylammonium bicarbonate

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
dimethylformamide

Reaktionsbedingungen

Temperatur
50°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

a solution of biotin-N-hydroxysuccinimide, 170 mg (0.5 mMoles), and tyramine (recrystallized from water), 68.5 mg (0.5 mMoles), in 25 ml dimethylformamide was treated with 10 ml of 1M triethylammonium bicarbonate, pH 7.5, and then heated at 50° C. for 3 hours.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05731158uspto-grants-1998_03