Reaktion #2693

Reaktionsgleichung

n-butyllithium

2,2,6,6-Tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxole

water

4-methoxycarbonyl-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole)

→

Bis-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxol-4-yl)-mono-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole-4-yl)methanol

Lösungsmittel

ether

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONfilled
2. 2
   Sonstigereaction vessel
3. 3
   Temperaturthe mixture was cooled to 0° C.
4. 4
   workup.STIRRINGThe reaction was stirred at ambient temperature overnight
5. 5
   SonstigeThe organic layer was separated
6. 6
   Waschenthe aqueous phase was washed once more with ether
7. 7
   TrocknenThe organic phase was dried (Na2SO4)
8. 8
   Sonstigeevaporated
9. 9
   Sonstigeto give a semisolid residue
10. 10
    SonstigeThe product was recrystallized from acetonitrile

Vorschrift

2,2,6,6-Tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxole (5.15 g, 23.2 mmol) was dissolved in dry ether (40.0 mL) in a dried, argon filled reaction vessel. The solution was cooled to 0° C. and n-butyllithium (9.29 mL, 2.5M in hexane) was added. After stirring for 15 min at ambient temperature, the mixture was cooled to 0° C. and 4-methoxycarbonyl-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole)(4.0 g, 11.6 mmol) was added portionwise. The reaction was stirred at ambient temperature overnight. The voluminous precipitate was dissolved by addition of water (70 mL) and ether (50 mL). The organic layer was separated and the aqueous phase was washed once more with ether. The organic phase was dried (Na2SO4) and evaporated to give a semisolid residue. The product was recrystallized from acetonitrile. Yield of pure product was 5.26 g (60%).

Quelle