Reaktion #2674

Reaktionsgleichung

trimethylborate

hydrochloric acid

hydrogen peroxide

3,4-difluoroanisole

N-butyllithium

→

expected product

2,3-difluoro 6-methoxy phenol

Lösungsmittel

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewere reacted at -72° C.

Vorschrift

Using the procedure of Example 39, 125 g of 3,4-difluoroanisole (commercial) and 500 ml of a 1.6M solution of N-butyllithium in hexane were reacted at -72° C., and then 92.4 ml of trimethylborate, 500 ml of hydrochloric acid and 120 g of intermediate compound were reacted and the product was reacted with 440 ml of 30% hydrogen peroxide to obtain 82.4 g of the expected product melting at 46.6° C.

Quelle