Reaktion #2670

Reaktionsgleichung

water

diphenyl diazomethane

acid

[3-fluoro-4,5-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-hydroxy-acetic acid

→

Diphenylmethyl [3-fluoro-4,5-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-hydroxy-acetate

Lösungsmittel

ether

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeby decanting
2. 2
   WaschenWashing with a saturated solution of sodium bicarbonate
3. 3
   Sonstigedrying
4. 4
   Sonstigeevaporating the solvents
5. 5
   Sonstigeyielded after chromatography on silica
6. 6
   Wascheneluting with an ethyl acetate

Vorschrift

5.3 g of the acid of Step A were dissolved in 66 ml of dichloromethane and then 46 ml of a solution of diphenyl diazomethane at 6.5 g in ether were added at 15° C. The mixture was stirred for 16 hours at ambient temperature and then water was added, followed by decanting and acidifying with acetic acid. Washing with a saturated solution of sodium bicarbonate, drying and evaporating the solvents yielded after chromatography on silica and eluting with an ethyl acetate--hexane mixture (50--50) 4.0 g of the desired product with a Rf=0.17.

Quelle