Reaktion #2663

Reaktionsgleichung

ethyl acetate

3-bromo-4-hydroxy-5-methoxy benzaldehyde

dimethyl acetamide

→

crude product

3-formyl-6-hydroxy-5-methoxy benzonitrile

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 2 hours
2. 2
   TemperaturAfter cooling
3. 3
   WaschenThe organic phase was washed
4. 4
   Sonstigedried

Vorschrift

A mixture of 23.1 g of 3-bromo-4-hydroxy-5-methoxy benzaldehyde, 9.3 g of cuprous cyanide and 140 ml of dimethyl acetamide (DMA) was refluxed for 2 hours with stirring. After cooling, the mixture was poured over ice and extract&d with an ethyl acetate--methanol mixture (90-10). The organic phase was washed and dried and the solvents were eliminated to obtain 18 g of crude product, which was used as is for the following step. It melted at 180° C.

Quelle