Reaktion #263

Reaktionsgleichung

COc1ccc(Br)cc1

COC(=O)C(C)(C)N

→

COC(=O)C(C)(C)Nc1ccc

Lösungsmittel

FC(F)(F)c1ccccc1

Reaktionsbedingungen

Vorschrift

1-bromo-4-methoxybenzene (0.060 mL, 0.47 mmol), methyl 2-amino-2-methylpropanoate (0.05 g, 0.43 mmol), sodium 2-methylbutan-2-olate (0.052 g, 0.47 mmol), diacetoxypalladium (2.68 mg, 0.01 mmol) and methyl 2-(4-methoxyphenylamino)-2-methylpropanoate (0.00 µg) was added to a microwave vial. (TRIFLUOROMETHYL)-BENZENE (0.5 mL) was used as solvent (1-1.2 mL/mmol amine). The mixture was heated in microwave at 180° for 60min. No conversion of startingmaterial was observed.

Quelle