Reaktion #2566

Reaktionsgleichung

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-tetrahydropyranyloxymethyl-N-(2-methoxyphenyl)benzene sulfonamide

p-toluenesulfonic acid monohydrate

sodium bicarbonate

→

title compound

Ausbeute 100.1%

N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-hydroxymethyl-N-(2-methoxyphenyl)benzene sulfonamide

Ausbeute 100.1%

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat room temperature
2. 2
   Sonstigewas removed by evaporation
3. 3
   Sonstigethe resulting reaction solution
4. 4
   Extraktionextracted with ethyl acetate
5. 5
   Waschenwashed with water and saturated brine
6. 6
   ExtraktionThe water layer was extracted with ethyl acetate
7. 7
   Waschenwashed with water and saturated brine
8. 8
   Trocknendried on anhydrous sodium sulfate
9. 9
   SonstigeThereafter, the solvent was removed by evaporation
10. 10
    Sonstigethe resulting residue was purified by a silica gel column chromatography (ethyl acetate)

Vorschrift

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-tetrahydropyranyloxymethyl-N-(2-methoxyphenyl)benzene sulfonamide (101 mg, 0.165 mmol) was dissolved in methanol (5 ml) to which was subsequently added p-toluenesulfonic acid monohydrate (35 mg, 0.18 mmol) at room temperature. After 2 hour of stirring at the same temperature, methanol was removed by evaporation, and the resulting reaction solution was mixed with saturated sodium bicarbonate aqueous solution (5 ml), extracted with ethyl acetate, and washed with water and saturated brine. The water layer was extracted with ethyl acetate, and washed with water and saturated brine, and the organic layers were combined and dried on anhydrous sodium sulfate. Thereafter, the solvent was removed by evaporation, and the resulting residue was purified by a silica gel column chromatography (ethyl acetate) to obtain 87 mg (100%) of the title compound in the form of colorless oil.

Quelle