Reaktion #2556

Reaktionsgleichung

4-(4-Fluorobenzoyl)piperidine

bromoacetoaldehyde diethylacetal

triethylamine

→

title compound

Ausbeute 25.0%

1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine

Ausbeute 25.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter 12 hours of heating
2. 2
   Temperaturunder reflux
3. 3
   Sonstigethe solvent was removed by evaporation
4. 4
   Sonstigethe resulting residue was purified

Vorschrift

4-(4-Fluorobenzoyl)piperidine (207 mg, 1.0 mmol) was dissolved in methylene chloride (5 ml) to which were subsequently added bromoacetoaldehyde diethylacetal (305 mg, 1.5 mmol) and triethylamine (0.5 ml). After 12 hours of heating under reflux, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 81 mg (25.0%) of the title compound in the form of orange oil.

Quelle