Reaktion #2552

Reaktionsgleichung

o-anisidine

triethylamine

sodium hydroxide

4-chloromethylbenzoyl chloride

2-bromomethyl-1,3-dioxolan

→

title compound

Ausbeute 47.9%

4-Chloromethyl-N-(2-methoxyphenyl)-N-(1,3-dioxolan-2-yl)methylbenzamide

Ausbeute 47.9%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwith cooling in an ice bath
2. 2
   workup.STIRRINGAfter 1 hour of stirring at the same temperature
3. 3
   Extraktionthe resulting mixture was extracted with methylene chloride
4. 4
   Waschenwashed with 10% citric acid aqueous solution and saturated brine
5. 5
   Trocknendried on anhydrous sodium sulfate
6. 6
   SonstigeThereafter, the solvent was removed by evaporation
7. 7
   Sonstigethe resulting residue was purified

Vorschrift

In an atmosphere of argon, a mixture consisting of o-anisidine (500 mg, 4.06 mmol), triethylamine (1.6 ml, 11.5 mmol) and 2-bromomethyl-1,3-dioxolan (0.96 ml, 8.18 mmol) was stirred at 80° C. for 4 days, dissolved in methylene chloride (8 ml) and then, with cooling in an ice bath, mixed with 20% sodium hydroxide aqueous solution (4 ml) and 4-chloromethylbenzoyl chloride (768 mg, 4.06 mmol). After 1 hour of stirring at the same temperature, the resulting mixture was extracted with methylene chloride, washed with 10% citric acid aqueous solution and saturated brine and then dried on anhydrous sodium sulfate. Thereafter, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ethyl acetate:hexane=2:5) to obtain 704 mg (47.9%) of the title compound in the form of colorless solid.

Quelle