Reaktion #2551

Reaktionsgleichung

4-Chloromethyl-N-(2-methoxyphenyl)benzamide

methylamine

→

title compound

Ausbeute 100.0%

N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide

Ausbeute 100.0%

Lösungsmittel

dioxane

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed by evaporation
2. 2
   workup.ADDITIONthe resulting residue was diluted with methylene chloride (10 ml)
3. 3
   TrocknenAfter drying on anhydrous sodium carbonate
4. 4
   Sonstigethe solvent was removed by evaporation

Vorschrift

4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.

Quelle