Reaktion #2509754

Reaktionsgleichung

2-Amino-N,3-dimethylbenzamide

sodium hydrogensulfite

para-anisaldehyde

→

compound

Ausbeute 49.0%

2-(4-methoxyphenyl)-3,8-dimethyl-4(3H)-quinazolinone

Ausbeute 49.0%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   workup.DISTILLATIONdistilled water (100 ml)
3. 3
   workup.ADDITIONwas added
4. 4
   workup.STIRRINGstirred at that temperature for 1 hour
5. 5
   FiltrationThe precipitated solid was taken out through filtration
6. 6
   Sonstigedried
7. 7
   Sonstigerecrystallized from hot ethanol

Vorschrift

2-Amino-N,3-dimethylbenzamide (4.10 g, 25.0 mmol), sodium hydrogensulfite (2.93 g, 27.5 mmol) and para-anisaldehyde (3.4 g, 25 mmol) were mixed in N,N′-dimethylacetamide (20 ml), stirred at 150° C. for 5 hours, then cooled to room temperature, and distilled water (100 ml) was added thereto and stirred at that temperature for 1 hour. The precipitated solid was taken out through filtration, dried, and recrystallized from hot ethanol to obtain the intended compound (3.42 g, 49%) as a white solid.

Quelle