Reaktion #2507902

ord-3146f8af39ab4069a516445f43acef1f

Reaktionsgleichung

COc1cc(N)ccc1OCCC1CCCO1
3-methoxy-4-(2-(tetrahydrofuran-2-yl)ethoxy)aniline
O=C(O)c1cc(-c2ccc(Cl)cc2)c[nH]1
4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid
COc1cc(NC(=O)c2cc(-c3ccc(Cl)cc3)c[nH]2)ccc1OCCC1CCCO1
title compound
Ausbeute 98.0%
COc1cc(NC(=O)c2cc(-c3ccc(Cl)cc3)c[nH]2)ccc1OCCC1CCCO1
4-(4-chlorophenyl)-N-(3-methoxy-4-(2-(tetrahydrofuran-2-yl)ethoxy)phenyl)-1H-pyrrole-2-carboxamide
Ausbeute 98.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Acylation of 3-methoxy-4-(2-(tetrahydrofuran-2-yl)ethoxy)aniline from step A with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid to generate the title compound in 98% yield was achieved via the procedure described in step C of Example 1. The crude product was used for next step without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07956049B2uspto-grants-2011_06