Reaktion #2507897

ord-890eb653ea8746c696ae03b42461d715

Reaktionsgleichung

COc1cc(N)ccc1-n1cncn1
3-Methoxy-4-(1H-1,2,4-triazol-1-yl)benzenamine
O=C(O)c1cc(-c2ccc(Cl)cc2)c[nH]1
4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid
COc1cc(NC(=O)c2cc(-c3ccc(Cl)cc3)c[nH]2)ccc1-n1cncn1
title compound
COc1cc(NC(=O)c2cc(-c3ccc(Cl)cc3)c[nH]2)ccc1-n1cncn1
4-(4-chlorophenyl)-N-(3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl)-1H-pyrrole-2-carboxamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3-Methoxy-4-(1H-1,2,4-triazol-1-yl)benzenamine, prepared as described in Bioorg. Med. Chem. Lett, 13:2059 (2003), was converted to the title compound (45 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (30 mg) following the procedure described in step C of Example 1. MS (ESI) 394 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07956049B2uspto-grants-2011_06