Reaktion #2507895

ord-46beba341bad43ef8e79ae7f0c39670a

Reaktionsgleichung

COc1cc(N)ccc1OCCNC(=O)OC(C)(C)C
tert-Butyl-(4-amino-2-methoxyphenoxy)ethylcarbamate
O=C(O)c1cc(-c2ccc(Cl)cc2)c[nH]1
4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid
→
COc1cc(NC(=O)c2cc(-c3ccc(Cl)cc3)c[nH]2)ccc1OCCNC(=O)OC(C)(C)C
title compound
COc1cc(NC(=O)c2cc(-c3ccc(Cl)cc3)c[nH]2)ccc1OCCNC(=O)OC(C)(C)C
tert-butyl 2-(4-(3-(4-chlorophenyl)-1H-pyrrole-5-carboxamido)-2-methoxyphenoxy)ethylcarbamate

Edukte

COc1cc(N)ccc1OCCNC(=O)OC(C)(C)C
tert-Butyl-(4-amino-2-methoxyphenoxy)ethylcarbamate
O=C(O)c1cc(-c2ccc(Cl)cc2)c[nH]1
4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

tert-Butyl-(4-amino-2-methoxyphenoxy)ethylcarbamate was converted to the title compound (80 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (25 mg) following the procedure described in step C of Example 1. MS (ESI) 386 (M-Boc)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07956049B2uspto-grants-2011_06