Reaktion #2507887

ord-ebb2f463262641e0b5cc1a2ce53f5db7

Reaktionsgleichung

Nc1ccc(OCCN2CCCC2)cc1
4-(2-(Pyrrolidin-1-yl)ethoxy)benzenamine
O=C(O)c1cc(-c2ccc(Cl)cc2)c[nH]1
4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid
O=C(Nc1ccc(OCCN2CCCC2)cc1)c1cc(-c2ccc(Cl)cc2)c[nH]1
title compound
Ausbeute 56.2%
O=C(Nc1ccc(OCCN2CCCC2)cc1)c1cc(-c2ccc(Cl)cc2)c[nH]1
4-(4-chlorophenyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrole-2-carboxamide
Ausbeute 56.2%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

4-(2-(Pyrrolidin-1-yl)ethoxy)benzenamine (35 mg) from step A was converted to the title compound (26 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (25 mg) following the procedure described in step C of Example 1. Step C. MS (ESI) 410 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07956049B2uspto-grants-2011_06