Reaktion #2507885

ord-64e7ae464c854f80ad748514fc00290a

Reaktionsgleichung

CN(C)CC1CCc2cc(N)ccc2C1
6-((dimethylamino)-methyl)-5,6,7,8-tetrahydronaphthalen-2-amine
O=C(O)c1cc(-c2ccc(Cl)cc2)c[nH]1
4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid
CN(C)CC1CCc2cc(NC(=O)c3cc(-c4ccc(Cl)cc4)c[nH]3)ccc2C1
title compound
CN(C)CC1CCc2cc(NC(=O)c3cc(-c4ccc(Cl)cc4)c[nH]3)ccc2C1
4-(4-chlorophenyl)-N-(6-((dimethylamino)methyl)-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrrole-2-carboxamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigepreparation

Vorschrift

Following preparation as described in WO 03/087046, 6-((dimethylamino)-methyl)-5,6,7,8-tetrahydronaphthalen-2-amine was converted to the title compound (8 mg) by acylation with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid (25 mg) following the procedure described in step C of Example 1. MS (ESI) 408 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07956049B2uspto-grants-2011_06