Reaktion #2507880

Reaktionsgleichung

Pyrrolidine

glycolic acid

→

title compound

Ausbeute 90.0%

2-hydroxy-1-(pyrrolidin-1-yl)ethanone

Ausbeute 90.0%

Lösungsmittel

o-xylene

o-xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile cooling in an ice bath
2. 2
   Temperaturheated
3. 3
   Sonstigewas removed by distillation

Vorschrift

Pyrrolidine (3.0 mL; 35.9 mmol) was added to glycolic acid (2.73 g; 35.9 mmol) over 5 minutes while cooling in an ice bath. The suspension was diluted with o-xylene (3.5 mL) and heated to reflux for 7 h whereupon the o-xylene was removed by distillation to afford the title compound (4.17 g; 90%) as an orange oil. 1H NMR (CDCl3) δ 1.86-4.92 (m, 2H), 1.96-2.02 (m, 2H), 3.26-3.29 (m, 2H), 3.52-3.55 (m, 3H), 4.08 (s, 2H); 13C NMR (CDCl3) δ 23.94, 25.74, 44.26, 45.96, 60.48, 169.90.

Quelle