Reaktion #2507875

Reaktionsgleichung

EtOH H2O

methyl 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylate

NaOH

→

title compound

Ausbeute 98.0%

4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid

Ausbeute 98.0%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed in vacuum
2. 2
   SonstigeAfter removal of traces of EtOH
3. 3
   FiltrationThe precipitate was collected by filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried in vacuum

Vorschrift

A 95:5 EtOH/H2O solution (5.0 mL) containing methyl 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylate (120 mg, 0.51 mmol) and NaOH (1.53 mol) was refluxed for 2 h whereupon the EtOH was removed in vacuum. After removal of traces of EtOH by azotroping twice with water, acidification to pH 3 with 1 M HCl generated a white precipitate. The precipitate was collected by filtration, washed with water, and dried in vacuum to give 110 mg (98%) of the title compound as a white solid. MS (ESI) 222 (M+H)+.

Quelle