Reaktion #2507870

ord-c8e435f2e4ba4ade88e4fd9f90a13335

Reaktionsgleichung

6-bromo-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol

$C/C=C\B(O)O$

(Z)-prop-1-enyl boronic acid

→

$C/C=C\c1cnc2nc(O)n(C(CC)CC)c2n1$

title compound

$C/C=C\c1cnc2nc(O)n(C(CC)CC)c2n1$

(Z)-1-(pentan-3-yl)-6-(prop-1-enyl)-1H-imidazo[4,5-b]pyrazin-2-ol

Edukte

6-bromo-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol

$C/C=C\B(O)O$

(Z)-prop-1-enyl boronic acid

—

(DPPF)PdCl2

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by reacting 6-bromo-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol (1.0 equiv), (Z)-prop-1-enyl boronic acid (1.5 equiv) and (DPPF)PdCl2 (0.15 equiv) in a manner analagous to Example 1(d). LCMS m/z (APCI)=247.0 (M+H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07956056B2uspto-grants-2011_06