Reaktion #2507867

Reaktionsgleichung

(S)-6-vinyl-1-(1-phenylethyl)-1H-imidazo[4,5-b]pyrazin-2-ol

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title compound

Ausbeute 86.0%

(S)-1-(1-phenylethyl)-6-ethyl-1H-imidazo[4,5-b]pyrazin-2-ol

Ausbeute 86.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA scintillation vial equipped with a stirbar
2. 2
   SonstigeThe resulting mixture was purged with hydrogen for 45 minutes
3. 3
   FiltrationThe mixture was then filtered through a pad of diatomaceous earth
4. 4
   Waschenthe pad of diatomaceous earth was washed twice with MeOH
5. 5
   EinengenThe solution was concentrated in vacuo

Vorschrift

A scintillation vial equipped with a stirbar was charged with (S)-6-vinyl-1-(1-phenylethyl)-1H-imidazo[4,5-b]pyrazin-2-ol (1.0 equiv), methanol (280 volume equivalents), and catalytic Pd/C. The resulting mixture was purged with hydrogen for 45 minutes; the reaction was complete as judged my LCMS. The mixture was then filtered through a pad of diatomaceous earth and the pad of diatomaceous earth was washed twice with MeOH. The solution was concentrated in vacuo. Flash chromatography (Biotage MPLC 5%-40% EtOAc/Hexanes) provided the title compound (86%) as a foam. LCMS m/z (APCI)=269.1 (M+H).

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