Reaktion #2507852

ord-a693cb8eb3e84d0fab3fca545e299992

Reaktionsgleichung

CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O
Eltrombopag
→
CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O.NCCO
Eltrombopag Mono-Ethanolamine

Edukte

CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O
Eltrombopag

Reagenzien

Keine

Lösungsmittel

CCCCCO
1-pentanol

Reaktionsbedingungen

Temperatur
70°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.WAITwas left
  2. 2
    Sonstigeto crystallize at 22° C
  3. 3
    SonstigeA precipitate formed
  4. 4
    Sonstigewas separated by filtration
  5. 5
    SonstigePXRD analysis provided the diffractogram

Vorschrift

Eltrombopag (15-20 mg) bisethanolamine was dissolved in 5 mL of 1-pentanol with heating to 70° C. and then was left to crystallize at 22° C. A precipitate formed and was separated by filtration and analysed. PXRD analysis provided the diffractogram as shown in FIG. 29.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07956048B2uspto-grants-2011_06