Reaktion #2507844

Reaktionsgleichung

2-propynyl 2-chloro-5-fluoro-4-(2-propynyloxy)benzoate

sodium hydroxide

hydrochloric acid

→

2-chloro-5-fluoro-4-(2-propynyloxy)benzoic acid

Ausbeute 61.4%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained above, and
2. 2
   FiltrationThen, a produced solid was collected by filtration
3. 3
   WaschenThe solid was washed with a MTBE-hexane mixed solvent

Vorschrift

To a mixture of 30 ml of methanol and 30 ml of a 15% aqueous sodium hydroxide solution was added 19 g of 2-propynyl 2-chloro-5-fluoro-4-(2-propynyloxy)benzoate obtained above, and then stirred at 50° C. for 2 hours. The reaction mixture was made acidic by addition of hydrochloric acid. Then, a produced solid was collected by filtration. The solid was washed with a MTBE-hexane mixed solvent, and 10 g of 2-chloro-5-fluoro-4-(2-propynyloxy)benzoic acid was obtained.

Quelle