Reaktion #2507841

Reaktionsgleichung

2-propynyl 2,5-difluoro-4-(2-propynyloxy)benzoate

sodium hydroxide

hydrochloric acid

→

2,5-difluoro-4-(2-propynyloxy)benzoic acid

Ausbeute 61.4%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationa produced solid was collected by filtration
2. 2
   SonstigeThe solid was dried
3. 3
   Waschenwashed with hexane

Vorschrift

To a mixture of 20 ml of methanol and 20 ml of a 15% aqueous sodium hydroxide solution was added 7.3 g of 2-propynyl 2,5-difluoro-4-(2-propynyloxy)benzoate, and the mixture was stirred at 50° C. for 2 hours. The reaction mixture was added to hydrochloric acid, and a produced solid was collected by filtration. The solid was dried and then washed with hexane, and 3.8 g of 2,5-difluoro-4-(2-propynyloxy)benzoic acid was obtained.

Quelle