Reaktion #2506267

Reaktionsgleichung

2-amino-5,6-dihydroxy-3,4-dihydro-1(2H)-naphthalenone hydrobromide

β-phenylpropionaldehyde

→

2-(3-phenylpropyl)amino-5,6-dihydroxy-3,4-dihydro-1(2H)-naphthalenone hydrobromide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeWhen a stoichiometric amount of hydrogen has been absorbed
2. 2
   Filtrationthe reaction mixture is filtered
3. 3
   Einengenthe filtrate is concentrated under reduced pressure

Vorschrift

In 300 volume parts of ethanol is dissolved 5 parts of 2-amino-5,6-dihydroxy-3,4-dihydro-1(2H)-naphthalenone hydrobromide and, after the addition of 50 parts of β-phenylpropionaldehyde, catalytic reduction is carried out at ordinary temperature and pressure using palladium-on-carbon as a catalyst. When a stoichiometric amount of hydrogen has been absorbed, the reaction mixture is filtered and the filtrate is concentrated under reduced pressure. The procedure yields 3.5 parts of 2-(3-phenylpropyl)amino-5,6-dihydroxy-3,4-dihydro-1(2H)-naphthalenone hydrobromide as colorless crystals melting at 215°-217° C.

Quelle