Reaktion #2500930

Reaktionsgleichung

glycylglycinamide

acetaldehyde

→

title compound

2-Methyl-5-oxo-1-imidazolidineacetamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeEvaporation of the solvent
2. 2
   Sonstigegave a residue which
3. 3
   Sonstigewas chromatographed on a silica gel column (eluant dichloromethane/methanol 75:25)
4. 4
   SonstigeThe selected fractions were collected
5. 5
   Sonstigeevaporated

Vorschrift

A solution of glycylglycinamide (0.5 g) and acetaldehyde (0.4 ml) in methanol (5 ml) was stirred at room temperature for 8 hours. Evaporation of the solvent gave a residue which was chromatographed on a silica gel column (eluant dichloromethane/methanol 75:25). The selected fractions were collected, evaporated to give the title compound (Rf=0.3, dichloromethane/methanol 7:3, silica gel plates). Mass spectrum (E.I., 70 eV, 1.5 mA), m/z=142 (M+ -CH3), 99.

Quelle