Reaktion #2499666

ord-1e671b23657547fda9e6b13a21b10116

Reaktionsgleichung

NCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1
4-(3-aminopropyl)-2-fluoro-1-triphenylmethylimidazole
CCN1CCN(C(=O)Cl)C(=O)C1=O
1-chlorocarbonyl-4-ethylpiperazine-2,3-dione
→
CCN1CCN(C(=O)NCCCc2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c(F)n2)C(=O)C1=O
4-[3-(2,3-dioxo-4-ethylpiperazine-1-carbonylamino)propyl]-2-fluoro-1-triphenylmethylimidazole

Edukte

NCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c(F)n1
4-(3-aminopropyl)-2-fluoro-1-triphenylmethylimidazole
CCN1CCN(C(=O)Cl)C(=O)C1=O
1-chlorocarbonyl-4-ethylpiperazine-2,3-dione

Reagenzien

CN(C)c1ccncc1
4-dimethylaminopyridine

Lösungsmittel

ClCCl
CH2Cl2
ClCCl
CH2Cl2

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Crude 4-(3-aminopropyl)-2-fluoro-1-triphenylmethylimidazole was dissolved in CH2Cl2 and treated with 4-dimethylaminopyridine and a solution of 1-chlorocarbonyl-4-ethylpiperazine-2,3-dione in CH2Cl2. Work-up by chromatography gave 4-[3-(2,3-dioxo-4-ethylpiperazine-1-carbonylamino)propyl]-2-fluoro-1-triphenylmethylimidazole, having the following n.m.r. spectrum in CDCl3 : 1.25 (t, 3H); 1.85 (quintet, 2H); 2.25-3.7 (m, 6H); 4.05 (q, 2H); 6.25 (s, 1H); 7.05-7.5 (m, 15H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04492692uspto-grants-1985_01